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Associations of psoriatic arthritis and cardiovascular conditions in a large population

Svetlana Kondratiouk, Natalia Udaltsova, Arthur L Klatsky

    The Permanente Journal
    |February 23, 2011
    PubMed

    Insights

    Psoriatic arthritis (PsA) is linked to higher rates of systemic hypertension and heart failure, but not other cardiovascular diseases. Further research is needed to clarify the association between PsA and cardiovascular risk factors.

    Area of Science:

    • Rheumatology
    • Cardiology
    • Inflammation

    Background:

    • Psoriatic arthritis (PsA) is a chronic inflammatory disease.
    • Shared inflammatory pathways may link PsA to cardiovascular (CV) conditions.

    Purpose of the Study:

    • To investigate the hypothesis that PsA is associated with an increased prevalence of CV conditions, potentially due to shared inflammatory mechanisms.

    Main Methods:

    • A multiethnic cohort of 76,465 individuals, including 99 with confirmed PsA diagnoses, was studied.
    • Logistic regression and t-tests were used to compare CV diagnoses and risk factors between PsA patients and matched controls.

    Main Results:

    • PsA patients showed increased prevalence of systemic hypertension and heart failure compared to controls.
    • PsA patients had higher mean body mass index and blood pressure, but similar blood glucose and lower cholesterol levels.
    • No increased prevalence of atherothrombotic disease or diabetes mellitus was observed in PsA patients.

    Conclusions:

    • The association between PsA and CV risk factors and conditions is mixed.
    • PsA is clearly associated with increased systemic hypertension, but its link to other CV diseases remains uncertain.
    Abstract

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