Related Experiment Video
Updated: Jun 4, 2026
Method of Studying Palatal Fusion using Static Organ Culture
Published on: September 19, 2015
[Study of patients with cleft lip and palate with consanguineous parents]
Sibele Nascimento de Aquino1, Lívia Máris Ribeiro Paranaíba, Daniella Reis Barbosa Martelli
1Estomatopatologia pela Universidade Estadual de Campinas - Unicamp, Brasil.
Unlabelled:
Cleft lip and/or palate (CL/P) are the most common congenital anomalies of the face. CL/P are non-syndromic (CL/PNS) in about 70% of subjects.
Aim:
To describe clinical cases of non-syndromic CL/P (CL/PNS) associated with consanguinity, diagnosed at a reference hospital in Minas Gerais, Brazil, and to correlate these alterations with possible risk factors. SERIES AND METHODS: A retrospective study at a reference hospital for craniofacial deformities in Minas Gerais, Brazil from 2006 to 2009 based on data in medical records.
Results:
Of 246 CL/PNS cases diagnosed and treated at the institution, 15 (6.1%) were CL/PNS with reported first-degree consanguinity; 73.3% occurred in males. Four of 15 patients had complete right cleft palate and lip (CLP), 4 presented complete cleft palate and lip (right and left), 3 had complete unilateral left CLP, 3 had isolated cleft palate, and 1 presented cleft lip only. Among the risk factors, only three mothers reported smoking during pregnancy.
Conclusions:
CLP (unilateral or bilateral) were more frequent in the group with a history of first-degree consanguinity; males predominated. Among the risk factors, only smoking was observed in three cases.
