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Symptomatic native arterial occlusions: early experience with "over-the-wire" thrombolysis
M W Mewissen1, P L Minor, G A Beyer
1Department of Radiology, Veterans Administration Medical Center, Milwaukee, WI 53295.
Journal of Vascular and Interventional Radiology : JVIR
|November 1, 1990
Summary
Over-the-wire thrombolysis effectively treated lower-extremity ischemia using urokinase infusion. This minimally invasive technique successfully dissolved arterial occlusions with no bleeding complications.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Cardiovascular Medicine
Background:
- Symptomatic lower-extremity ischemia often results from arterial occlusions.
- Traditional treatments may carry significant risks or limitations.
Purpose of the Study:
- To evaluate the efficacy and safety of "over-the-wire" thrombolysis for treating lower-extremity arterial occlusions.
- To assess the use of a specific catheter system for targeted urokinase delivery.
Main Methods:
- Eight patients with symptomatic lower-extremity ischemia underwent the procedure.
- A 5-F catheter with side holes was used to deliver urokinase over a 0.035-inch guide wire.
- Mean occlusion length was 11.5 cm, treated with a mean of 480,000 IU of urokinase over 48 minutes.
Main Results:
- Complete thrombolysis was achieved in all patients.
- One embolic complication occurred but was successfully managed with the same system.
- No bleeding complications were reported, indicating a favorable safety profile.
Conclusions:
- "Over-the-wire" thrombolysis is a viable and safe alternative for administering urokinase in treating arterial occlusions.
- The technique demonstrated high efficacy in resolving lower-extremity ischemia.