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Problems in diabetes mellitus management. Insulin resistance
1Department of Veterinary Physiology, Pharmacology & Toxicology, School of Veterinary Medicine, Lousiana State University, Baton Rouge 70803.
Problems in Veterinary Medicine
|December 1, 1990
Summary
Morning hyperglycemia in diabetic patients can stem from insulin resistance. Identifying and addressing the root cause of insulin resistance is crucial for effective diabetes management and treatment.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Internal Medicine
Background:
- Insulin resistance is a significant factor contributing to morning hyperglycemia in diabetic individuals.
- Other potential causes of elevated blood glucose levels in the morning must be ruled out.
Purpose of the Study:
- To outline a diagnostic approach for identifying insulin resistance as the cause of morning hyperglycemia.
- To detail a systematic method for determining the underlying causes of insulin resistance.
Main Methods:
- Performing an insulin response test to differentiate causes of morning hyperglycemia.
- Systematic evaluation to identify specific causes of established insulin resistance.
Main Results:
- Common causes of insulin resistance include hyperadrenocorticism, acromegaly, hyperthyroidism, obesity, hepatic disease, renal insufficiency, and sepsis.
- Less frequent causes encompass insulin antibodies, pregnancy, neoplasia, hyperandrogenism, and pheochromocytoma.
Conclusions:
- Establishing insulin resistance as the cause of morning hyperglycemia necessitates a step-by-step diagnostic process.
- If the underlying cause of insulin resistance remains unresolved, increased insulin dosage is required for glycemic control.