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Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Compartmentalized protein kinase C activation in ovarian carcinoma cells
1Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX.
Abstract:
Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinases, plays a cardinal role in malignancy (1-5). PKC isozymes can be categorized into three groups: Group A or conventional (c) PKC: α, βI, βII, and γ; Group B or novel (n) PKC: δ, ε, η, θ, and µ, and Group C or atypical (a) PKC: ζ and λ (ι) (1,3,4). Whereas cPKCs require Ca(2+)and diacylglycerol (DAG) phorbol esters for their activities, nPKCs and aPKCs are Ca(2+)-independent. aPKCs are also insensitive to diacylglycerol and phorbol esters (1,3,4).
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