Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview Of Cell Separation And Isolation

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Categorical framework for quantum-resistant zero-trust AI security.

Scientific reports·2026

Same author

Provision of Interventional Radiology 3rd Edition - should we not include all stakeholders?

Cardiovascular and interventional radiology·2024

Same author

The variability in interpretation of colonic codes in CT colonography reporting: a single-centre experience.

Clinical radiology·2024

Same author

Novel Measurement of the Neutron Magnetic Form Factor from A=3 Mirror Nuclei.

Physical review letters·2024

Same author

Survey of rectal cancer MRI technique and reporting tumour descriptors in the UK: a multi-centre British Society of Gastrointestinal and Abdominal Radiology (BSGAR) audit.

Clinical radiology·2023

Same author

Bacterial production of recombinant contraceptive vaccine antigen from CatSper displayed on a human papilloma virus-like particle.

Vaccine·2023

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Immunomagnetic Isolation of the Vascular Wall-Resident CD34+ Stem Cells from Mice

Immunomagnetic Isolation of the Vascular Wall-Resident CD34⁺ Stem Cells from Mice

Published on: December 22, 2023

Immunomagnetic cell separation.

C Clarke¹, S Davies

¹LICR/UCL Breast Cancer Laboratory, Department of Surgery, Royal Free and University College Medical School, London, UK.

Methods in Molecular Medicine

|February 23, 2011

Summary

This summary is machine-generated.

Magnetic bead separation is a popular method for isolating tumor cells from complex samples like blood or bone marrow. This technique also enables the separation of normal cells for direct comparison in metastasis research.

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Isolation and Activation of Murine Lymphocytes

Isolation and Activation of Murine Lymphocytes

Published on: October 30, 2016

Related Experiment Videos

Last Updated: Jun 4, 2026

Immunomagnetic Isolation of the Vascular Wall-Resident CD34+ Stem Cells from Mice

Immunomagnetic Isolation of the Vascular Wall-Resident CD34⁺ Stem Cells from Mice

Published on: December 22, 2023

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Isolation and Activation of Murine Lymphocytes

Isolation and Activation of Murine Lymphocytes

Published on: October 30, 2016

Area of Science:

Oncology
Cell Biology
Biotechnology

Background:

Accurate separation of tumor cells from mixed populations is crucial for metastasis research.
Direct comparison with normal cell counterparts aids in understanding tumor biology.

Purpose of the Study:

To highlight the utility of magnetic bead separation techniques.
To underscore the importance of cell separation in metastasis studies.

Main Methods:

Magnetic bead separation techniques are increasingly employed.
These methods allow for the isolation of specific cell populations.

Main Results:

Tumor cells can be effectively separated from diverse sources including tumors, peripheral blood, and bone marrow.
Normal cell populations can be isolated for comparative analyses.

Conclusions:

Magnetic bead separation offers a valuable tool for advancing metastasis research.
The technique facilitates detailed study of tumor cell behavior and interactions.