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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Related Experiment Video

Updated: Jun 4, 2026

A Customizable Chamber for Measuring Cell Migration
07:33

A Customizable Chamber for Measuring Cell Migration

Published on: March 12, 2017

Cell migration and the boyden chamber.

N S Brown1, R Bicknell

  • 1Molecular Angiogenesis Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Methods in Molecular Medicine
|February 23, 2011
PubMed
Summary
This summary is machine-generated.

Tumor cell migration and blood vessel growth (angiogenesis) are key to cancer spreading. Understanding how tumor cells and endothelial cells move is crucial for developing new cancer treatments.

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Last Updated: Jun 4, 2026

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Evaluation of the Cell Invasion and Migration Process: A Comparison of the Video Microscope-based Scratch Wound Assay and the Boyden Chamber Assay
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Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Metastasis Research

Background:

  • Tumor cells spread to secondary sites through blood or lymphatic vessels.
  • Cancer cell migration speed influences metastasis by affecting the distance to these vessels.
  • Angiogenesis, or blood vessel growth into tumors, promotes tumor spread and metastasis.

Purpose of the Study:

  • To investigate tumor cell line responses to motility-boosting factors.
  • To examine endothelial cell chemotaxis in response to tumor-derived angiogenic factors.
  • To understand the mechanisms of cancer cell and endothelial cell migration in metastasis.

Main Methods:

  • Assessing tumor cell line migration in response to specific factors.
  • Analyzing endothelial cell behavior and chemotaxis towards tumor-secreted factors.
  • Utilizing in vitro models to study cell motility and invasion.

Main Results:

  • Identified specific factors that enhance tumor cell migration.
  • Characterized the chemotactic responses of endothelial cells to tumor-derived signals.
  • Demonstrated the link between cell migration dynamics and metastatic potential.

Conclusions:

  • Understanding tumor cell and endothelial cell migration is vital for controlling cancer metastasis.
  • Motility factors and angiogenic signaling play critical roles in tumor spread.
  • Further research into these migratory processes can inform therapeutic strategies.