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Related Experiment Video

Updated: Jun 4, 2026

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds
10:16

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds

Published on: June 6, 2015

Chick heart invasion assay.

M E Bracke1, T Boterberg, M M Mareel

  • 1Laboratory of Experimental Cancerology, Department of Radiotherapy, Nuclear Medicine and Experimental Cancerology, University Hospital Gent, Gent, Belgium.

Methods in Molecular Medicine
|February 23, 2011
PubMed
Summary

Tumors are complex microecosystems where cancer and host cells interact. Organ culture models using embryonic chick hearts allow studying this cross-talk and its effect on tumor invasion.

Area of Science:

  • Oncology
  • Developmental Biology
  • Cell Biology

Background:

  • Tumors function as microecosystems with constant communication between cancer and host cells, influencing overall tumor invasiveness.
  • This cellular cross-talk involves secreted factors that regulate cell-matrix interactions, adhesion, matrix remodeling, and motility.

Purpose of the Study:

  • To investigate the interactions between cancer cells and host tissues within an organ culture system.
  • To utilize embryonic chick heart fragments as a model for studying tumor cell invasion and host tissue responses.

Main Methods:

  • Organ culture of embryonic chick heart fragments.
  • Co-culture of cancer cells with living normal host tissue.
  • Monitoring of tissue functional integrity through contractility.

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Last Updated: Jun 4, 2026

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds
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Published on: June 6, 2015

Chick ex ovo Culture and ex ovo CAM Assay: How it Really Works
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Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
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Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

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Main Results:

  • Embryonic chick heart fragments retain histological features and cellular composition (myocytes, fibroblasts, endothelial cells).
  • The extracellular matrix (ECM) of the heart fragments contains key components like fibronectin, laminin, and collagens.
  • The contractile activity of the heart fragments serves as an indicator of their viability and functional integrity during culture.

Conclusions:

  • Organ culture systems provide a viable model for studying the complex tumor microenvironment.
  • Embryonic chick heart fragments offer a robust model for investigating cancer cell invasion and host tissue interactions.