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Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

Transgenic Plants

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

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Related Experiment Video

Updated: Jun 4, 2026

Generation of Transgenic Rats using a Lentiviral Vector Approach

Generation of Transgenic Rats using a Lentiviral Vector Approach

Published on: May 17, 2020

Transgenic animal models.

C T Guy¹, G Cardoso

¹Ardais Corporation, Lexington, MA.

Methods in Molecular Medicine

|February 23, 2011

Summary

Cancer metastasis, the spread of cancer cells, is a complex genetic process. Understanding the molecular basis of this spread is crucial for advancing cancer research and treatment strategies.

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Cancer is a widespread and complex human disease.
It is understood as a multistep genetic process where cells acquire aberrations.
Cancer cell metastasis, the spread to distant tissues, is a poorly understood aspect of oncogenesis.

Purpose of the Study:

To investigate the molecular mechanisms driving cancer cell metastasis.
To address the challenge of understanding how tumor cells spread from primary sites.

Main Methods:

This study focuses on the molecular basis of cancer cell metastasis.
It examines the genetic and phenotypic changes enabling cancer cell spread.

Main Results:

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Last Updated: Jun 4, 2026

Generation of Transgenic Rats using a Lentiviral Vector Approach

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Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm

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The study highlights that cancer metastasis involves a series of independent genetic events.

These events lead to incremental phenotypic aberrations, such as extended proliferation and tissue invasion.

Conclusions:

Understanding the molecular underpinnings of metastasis is critical for cancer research.
Further investigation into these mechanisms is needed to combat cancer progression.