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Related Experiment Video

Updated: Jun 4, 2026

Aortic Ring Assay

Aortic Ring Assay

Published on: November 24, 2009

Disc angiogenesis assay.

A C Allison¹, L F Fajardo

¹SurroMed Inc, Palo Alto, CA.

Methods in Molecular Medicine

|February 23, 2011

Summary

This summary is machine-generated.

Researchers developed a quantitative assay for angiogenesis in mice. This method utilizes the mouse model for studying angiogenic factors and inhibitors efficiently.

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Related Experiment Videos

Last Updated: Jun 4, 2026

Aortic Ring Assay

Aortic Ring Assay

Published on: November 24, 2009

Rat Mesentery Angiogenesis Assay

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay

Investigating Angiogenesis on a Functional and Molecular Level by Leveraging the Scratch Wound Migration Assay and the Spheroid Sprouting Assay

Published on: May 31, 2024

Area of Science:

Biomedical research
Mammalian physiology
Experimental biology

Background:

Angiogenesis, the formation of new blood vessels, is crucial in various physiological and pathological processes.
Mice are ideal experimental models due to their size, genetic diversity, and availability of genetically modified strains.
Using species-specific growth factors enhances the relevance of experimental findings.

Purpose of the Study:

To establish a quantitative assay for measuring angiogenesis in mice.
To provide a standardized method for evaluating angiogenic factors and inhibitors.
To leverage the advantages of the mouse model for angiogenesis research.

Main Methods:

Development of a novel quantitative assay for angiogenesis.
Utilizing genetically diverse mouse strains and histocompatible tumors.
Employing recombinant growth factors and proteins relevant to the experimental animal.

Main Results:

A functional quantitative assay for angiogenesis in mice was successfully developed.
The assay allows for efficient experimentation with angiogenic factors and inhibitors.
The study highlights the utility of genetically engineered mice in angiogenesis research.

Conclusions:

The developed quantitative assay provides a valuable tool for mammalian angiogenesis studies.
The mouse model offers significant advantages for research on blood vessel formation.
This assay facilitates the investigation of growth factors and inhibitors in vivo.