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Related Experiment Video

Updated: Jun 4, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

10 Lipoprotein(a) Quantitation.

M Bender¹, W Gross

¹Gustav Embden Centre of Biological Chemistry, Johann Wolfgang Goethe University, Frankfurt-am-Main, Germany.

Methods in Molecular Medicine

|February 23, 2011

Summary

This summary is machine-generated.

Lipoprotein(a) (Lp[a]) is a key risk factor for coronary heart disease. This lipoprotein particle resembles LDL but contains an additional glycoprotein, apolipoprotein(a) (apo[a]).

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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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Published on: May 9, 2019

Area of Science:

Biochemistry
Cardiovascular Science
Lipidology

Background:

Lipoprotein(a) (Lp[a]) was discovered in 1963 as a beta-lipoprotein variant.
Lp[a] is recognized as an independent risk factor for coronary heart disease.
Recent decades have focused on investigating Lp[a]'s structure and composition.

Purpose of the Study:

To detail the structure and composition of Lp(a).
To elucidate the role of apolipoprotein(a) (apo[a]) in Lp(a) structure.

Main Methods:

Physicochemical analysis of Lp(a) particles.
Biochemical characterization of Lp(a) components.

Main Results:

Lp(a) shares structural similarities with low-density lipoprotein (LDL).
Lp(a) contains an additional glycoprotein, apolipoprotein(a) (apo[a]), primarily synthesized in the liver.
Apo(a) is linked via a disulfide bridge to apolipoprotein B-100 (apoB-100).
Apo(a) is thought to be loosely attached to the Lp(a) particle surface, unlike the structural role of apoB-100.

Conclusions:

Lp(a) is structurally distinct from LDL due to the presence of apo[a].
The specific role of apo[a] in Lp[a] function and pathogenicity warrants further investigation.