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Plasma fibronectin level in erysipelas.
M M Massoud1, B A Mahmoud, M R Gadballa
1Tropical, Clinical Pathology and Community Medicine Department, Faculty of Medicine, Ain Shams University.
The Journal of the Egyptian Public Health Association
|January 1, 1990
Summary
Plasma fibronectin levels were significantly lower in erysipelas patients compared to healthy controls. This finding suggests fibronectin may have prognostic and therapeutic value in treating bacterial infections.
Area of Science:
- Clinical Medicine
- Biochemistry
- Infectious Diseases
Background:
- Erysipelas is a bacterial skin infection.
- Plasma fibronectin is a protein involved in immune response and tissue repair.
- The role of fibronectin in erysipelas is not well understood.
Purpose of the Study:
- To investigate plasma fibronectin levels in patients with erysipelas.
- To compare fibronectin levels between erysipelas patients and healthy controls.
- To explore the potential prognostic and therapeutic implications of fibronectin in erysipelas.
Main Methods:
- Plasma fibronectin levels were measured in 20 patients diagnosed with erysipelas.
- Plasma fibronectin levels were measured in 10 healthy individuals serving as controls.
- Statistical analysis was performed to compare fibronectin levels between the two groups.
Main Results:
- Patients with erysipelas exhibited significantly lower plasma fibronectin levels (134 +/- 7.4 g./ml) compared to normal controls (352.6 +/- 42.9 g./ml).
- The difference in fibronectin levels was statistically significant (p < 0.001).
Conclusions:
- Low plasma fibronectin levels are associated with erysipelas.
- Plasma fibronectin levels may serve as a prognostic indicator for erysipelas.
- Fibronectin replacement therapy could be a potential treatment strategy for erysipelas and severe bacterial sepsis.