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Faster, quantitative, and accurate precursor acquisition independent from ion count

Alexandre Panchaud1, Sunhee Jung, Scott A Shaffer

  • 1Department of Medicinal Chemistry, University of Washington, Seattle, Washington, United States.

Analytical Chemistry
|February 24, 2011
PubMed
Summary

This study introduces a faster, quantitative method called precursor acquisition independent from ion count (PAcIFIC) for shotgun proteomics. PAcIFIC improves detectable dynamic range, enabling monitoring of low-abundance proteins without sample prefractionation.

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