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Pore formation in phospholipid bilayers by branched-chain pyrogallol[4]arenes
Saeedeh Negin1, Megan M Daschbach, Oleg V Kulikov
1Center for Nanoscience, Department of Chemistry & Biochemistry, University of Missouri-Saint Louis, Saint Louis, Missouri 63121, United States.
Abstract:
Pyrogallolarenes are tetrameric macrocycles that form from 1,2,3-trihydroxybenzene and aldehydes under acidic conditions. When 2-ethylbutanal or 2-propylpentanal was so treated, the branched-chain pyrogallolarenes crystallized as nanotubes or bilayers, respectively. When the behavior of each compound was assessed by using the planar bilayer conductance method, pore formation was observed. The properties of the pores were significantly different from each other, probably reflecting different types of pore organization within the membrane.
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