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Related Concept Videos

Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular cargos...

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Related Experiment Video

Updated: Jun 4, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

DNA-based optomechanical molecular motor.

Martin McCullagh1, Ignacio Franco, Mark A Ratner

  • 1Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States.

Journal of the American Chemical Society
|February 24, 2011
PubMed
Summary
This summary is machine-generated.

This study presents an optically triggered DNA motor. It uses azobenzene isomerization to perform work, achieving 3.4 kcal/mol work per cycle with 2.4% efficiency.

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Area of Science:

  • Molecular Biophysics
  • Nanotechnology
  • Photochemistry

Background:

  • Single-molecule manipulation techniques are crucial for understanding molecular mechanisms.
  • Optically controlled molecular machines offer precise control over nanoscale operations.
  • DNA nanostructures provide a versatile platform for designing molecular devices.

Purpose of the Study:

  • To develop and characterize an optically triggered single-molecule motor using an azobenzene-capped DNA hairpin.
  • To investigate the impact of azobenzene photoisomerization on DNA hairpin stability and mechanics.
  • To quantify the work output and efficiency of the optomechanical cycle.

Main Methods:

  • Coupling an azobenzene-capped DNA hairpin to an Atomic Force Microscope (AFM).
  • Utilizing molecular dynamics (MD) simulations and free energy calculations.
  • Monitoring molecular unfolding along the O5'-O3' extension coordinate.

Main Results:

  • Photoisomerization of azobenzene alters DNA hairpin length and base-pairing stability.
  • Potentials of Mean Force (PMFs) reveal differences in interbase interactions and chain length between isomers.
  • A maximum of 3.4 kcal/mol of work per cycle was extracted with an estimated efficiency of 2.4%.

Conclusions:

  • The azobenzene-DNA hairpin functions as an effective optically triggered single-molecule motor.
  • Photoisomerization-induced changes in DNA structure are key to work extraction.
  • The study provides structure-function insights and characterizes the influence of cantilever stiffness on motor performance.