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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Palliative therapy for osteosarcoma.

Costantino Errani1, Alessandra Longhi, Giuseppe Rossi

  • 1Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, via Pupilli n1, cap 40136 Bologna, Italy.

Expert Review of Anticancer Therapy
|February 24, 2011
PubMed
Summary
This summary is machine-generated.

Outcomes for metastatic, recurrent, or unresectable osteosarcoma remain poor despite advances. New targeted therapies and experimental approaches are crucial for improving survival in these challenging cases.

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Area of Science:

  • Orthopedics
  • Medical Oncology
  • Surgical Oncology

Background:

  • Metastatic, recurrent, or unresectable osteosarcoma presents a significant challenge with poor progression-free survival rates.
  • Current therapeutic strategies, including neoadjuvant chemotherapy and limb-salvage surgery, have limited efficacy in improving outcomes for these patient subgroups.
  • Existing treatment options are often controversial and limited, necessitating exploration of novel therapeutic avenues.

Purpose of the Study:

  • To review current therapeutic strategies for metastatic, recurrent, or unresectable osteosarcoma.
  • To highlight the limitations of existing treatments and the urgent need for improved survival outcomes.
  • To emphasize the necessity of developing new experimental and targeted therapies for advanced osteosarcoma.

Main Methods:

  • Review of current literature on therapeutic strategies for advanced osteosarcoma.
  • Analysis of the roles of systemic and localized therapies, including surgery, chemotherapy, radiotherapy, embolization, and thermal ablation.
  • Identification of gaps in treatment and areas for future research.

Main Results:

  • Surgical resection remains the standard of care when feasible for advanced osteosarcoma.
  • The role of chemotherapy in advanced osteosarcoma is not clearly defined.
  • There is an increasing utilization of radiotherapy, embolization, and thermal ablation in treatment protocols.

Conclusions:

  • Despite advancements, progression-free survival for metastatic, recurrent, or unresectable osteosarcoma is poor.
  • Novel therapeutic experimental approaches and targeted therapies are essential to improve outcomes.
  • Further research is needed to establish effective treatment paradigms for these difficult-to-treat osteosarcoma cases.