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Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

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Related Experiment Video

Updated: Jun 4, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
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Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

Necrobacillosis in humans.

Gunnar Dahlén1, Anders Ebenfelt

  • 1Department of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy at University of Gothenburg, PO Box 450, SE-405 30 Gothenburg, Sweden. dahlen@odontologi.gu.se

Expert Review of Anti-Infective Therapy
|February 24, 2011
PubMed
Summary

Necrobacillosis, a rare infection caused by Fusobacterium necrophorum, involves peritonsillar abscess and thrombophlebitis, potentially leading to fatal septicemia. Early diagnosis of this

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Otolaryngology

Background:

  • Necrobacillosis, also known as Lemierre's syndrome, is a severe infection characterized by peritonsillar abscess and internal jugular vein thrombophlebitis.
  • It is caused by the anaerobic bacterium Fusobacterium necrophorum, which can lead to life-threatening bacteremia and septicemia.
  • Often termed the 'forgotten disease,' necrobacillosis is frequently underdiagnosed in its milder forms, such as tonsillitis and peritonsillar abscess.

Purpose of the Study:

  • To highlight the etiological role of Fusobacterium necrophorum in necrobacillosis and related conditions.
  • To emphasize the importance of recognizing and diagnosing necrobacillosis, including its milder presentations.
  • To discuss diagnostic methods and therapeutic strategies for necrobacillosis.

Main Methods:

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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

  • Review of clinical presentations and etiological factors of necrobacillosis.
  • Identification of Fusobacterium necrophorum through swab samples and blood cultures.
  • Analysis of treatment protocols, including antibiotic therapies.

Main Results:

  • Fusobacterium necrophorum is implicated in Lemierre's syndrome, noma (cancrum oris), tonsillitis, and peritonsillar abscess.
  • Early recognition of milder forms is crucial for timely intervention.
  • Diagnosis relies on detecting F. necrophorum in clinical specimens.

Conclusions:

  • Necrobacillosis, though rare, requires increased clinical awareness due to its potential for severe complications.
  • Prompt diagnosis and appropriate antibiotic treatment, commonly with metronidazole and penicillin/amoxicillin or clindamycin, are essential for favorable outcomes.
  • Further research may elucidate the full spectrum and optimal management of necrobacillosis complex infections.