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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Related Experiment Video

Updated: Jun 4, 2026

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
06:01

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

Published on: April 21, 2021

Self assembling polymers as polymersomes for drug delivery.

Jay Prakash Jain1, Wubeante Yenet Ayen, Neeraj Kumar

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Sector 67, S.A.S. Nagar-160062, India.

Current Pharmaceutical Design
|February 24, 2011
PubMed
Summary
This summary is machine-generated.

Polymersomes, self-assembled vesicles, are versatile drug delivery systems. Their formation and morphology depend on copolymer properties, specifically the hydrophilic-to-hydrophobic block ratio.

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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
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Last Updated: Jun 4, 2026

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
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Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
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Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
08:45

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration

Published on: May 26, 2016

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Polymersomes are self-assembled vesicular structures formed from amphiphilic block copolymers.
  • Their unique properties, including stability and capacity for both hydrophilic and hydrophobic drug loading, make them promising for drug delivery applications.
  • The formation of polymersomes and their resulting morphologies are critically dependent on specific physicochemical parameters of the constituent copolymers.

Purpose of the Study:

  • To review the fundamental aspects of polymersomes as drug delivery systems.
  • To discuss various amphiphilic copolymers used in polymersome preparation.
  • To explore the potential applications of polymersomes in advanced drug delivery.

Main Methods:

  • Review of existing literature on polymersome self-assembly and characterization.
  • Analysis of the influence of copolymer composition, particularly the hydrophilic-to-hydrophobic block ratio, on polymersome formation.
  • Compilation of data on diverse copolymer architectures and their impact on morphology.

Main Results:

  • Polymersome formation and morphology are highly sensitive to the hydrophilic-to-hydrophobic block ratio of the copolymer.
  • Different amphiphilic copolymers exhibit distinct requirements for this ratio to achieve desired vesicular structures.
  • A variety of copolymer architectures can be employed to create polymersomes with tunable properties.

Conclusions:

  • Understanding the critical hydrophilic-to-hydrophobic block ratio is essential for designing effective polymersomes for drug delivery.
  • The choice of amphiphilic copolymer significantly influences polymersome characteristics and their suitability for specific applications.
  • Polymersomes represent a versatile platform with substantial potential for future advancements in drug delivery technology.