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Developmental outcomes among 18-month-old Malawians after a year of complementary feeding with lipid-based nutrient
John C Phuka1, Melissa Gladstone, Kenneth Maleta
1College of Medicine, University of Malawi, Blantyre, Malawi. johnphuka@yahoo.co.uk
Insights
This study compared infant development using lipid-based nutrient supplements versus fortified corn-soy porridge. Both feeding strategies resulted in similar developmental outcomes for Malawian infants by 18 months.
Area of Science:
- Pediatrics
- Nutrition Science
- Developmental Psychology
Background:
- Infant malnutrition is a significant public health issue in rural Malawi.
- Complementary feeding strategies are crucial for optimal child development.
- Assessing the impact of different nutritional supplements on infant development is essential.
Purpose of the Study:
- To compare the developmental outcomes of 18-month-old infants receiving complementary feeding for one year.
- To evaluate the efficacy of lipid-based nutrient supplements (FS50, FS25) against micronutrient-fortified corn-soy porridge (Likuni Phala - LP).
- To identify socio-economic factors associated with developmental outcomes in rural Malawian infants.
Main Methods:
- A randomized controlled trial involving 163 six-month-old rural Malawian infants.
- Intervention groups received daily supplementation with FS50, FS25, or LP for 12 months.
- Griffiths' developmental scores were assessed at 0-2 years; data analyzed using ANOVA and multiple regression.
Main Results:
- No significant differences in mean mental ages, raw developmental scores, or developmental quotients were observed among the LP, FS50, and FS25 groups at 18 months.
- Length-for-age z-score gain and maternal education were significantly associated with developmental outcomes (P=0.03 and P=0.04, respectively).
Conclusions:
- Daily supplementation with lipid-based nutrient supplements or fortified corn-soy flour for 12 months resulted in comparable infant development outcomes at 18 months.
- Socio-economic factors, including maternal education and nutritional status (length-for-age z-score gain), play a role in infant development.
- Both tested nutritional interventions appear effective in supporting infant development in this rural Malawian population.
Abstract:
The major aim of this trial was to compare the development of 18-month-old infants who received complementary feeding for 1 year either with lipid-based nutrient supplements or micronutrient fortified corn-soy porridge. Our secondary aim was to determine the socio-economic factors associated with developmental outcomes in the same population. A total of 163 six-month-old rural Malawian children were enrolled in a randomized controlled trial where the control population received daily supplementation with 71 g corn-soy flour [Likuni Phala (LP)] (282 kcal) and individuals in the intervention groups received daily either 50 g of lipid-based nutrient supplement (FS50) (264 kcal) or 25 g of lipid-based nutrient supplement (FS25) (130 kcal). The main outcome measures were Griffiths' developmental scores at 0-2 years. Independent comparison of study groups was carried out using analysis of variance (ANOVA) statistics where mean raw scores, quotients, or mental ages were compared. Association of developmental outcome with predictor variables were examined using multiple regression. At 18 months of chronological age, the mean ± standard deviation (SD) mental ages in the LP, FS50, and FS25 groups were 17.9 ± 1.3, 17.9 ± 1.3, and 17.9 ± 1.2 (P > 0.99), respectively. Likewise, the mean raw developmental scores and mean developmental quotients did not differ significantly. Length-for-age z-score gain during the intervention period, and maternal education were associated with developmental outcome at 18 months (P = 0.03 and P = 0.04; respectively). In conclusion, rural Malawian infants receiving 12-month daily supplementation of their diet either with the tested lipid-based nutrient supplements or fortified corn-soy flour have comparable development outcomes by 18 months of age.
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