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Published on: August 8, 2022
[Clinical analysis of 68 cases of childhood dilated cardiomyopathy]
Yan-Yan Han1, Shu-Bo Zhai, Jing-Hui Sun
1Department of Pediatric Cardiovascular, First Hospital of Jilin University, Changchun 130021, China.
Insights
In children with dilated cardiomyopathy (DCM), abnormal electrocardiogram (ECG) findings like sinus tachycardia are common. Arrhythmia occurrence is linked to enlarged left ventricular size and impaired heart function.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Research
- Clinical Electrophysiology
Context:
- Dilated cardiomyopathy (DCM) in children presents unique challenges in diagnosis and management.
- Electrocardiogram (ECG) abnormalities are frequently observed in pediatric DCM.
- Understanding the relationship between ECG findings and cardiac function is crucial for risk stratification.
Purpose:
- To investigate the specific ECG characteristics in pediatric patients diagnosed with DCM.
- To identify factors associated with the development of secondary arrhythmias in children with DCM.
- To correlate ECG findings with left ventricular dimensions and systolic function.
Summary:
- All 68 children with DCM exhibited abnormal ECGs, with sinus tachycardia and ectopic pulsatile rhythms being most prevalent.
- Significant differences in left ventricular end-diastolic diameter (LVED), left ventricular ejection fraction (LVEF), and left ventricular fractional shortening (LVFS) were observed across groups with varying arrhythmia severity.
- Increased LVED and decreased LVEF/LVFS were associated with more severe arrhythmias, indicating a link between cardiac remodeling, function, and arrhythmia occurrence.
Impact:
- This study highlights common ECG findings in pediatric DCM, emphasizing arrhythmia as a key clinical manifestation.
- The findings underscore the association between left ventricular structural and functional changes and the propensity for arrhythmias in this population.
- Provides valuable insights for clinicians in assessing arrhythmia risk and managing pediatric DCM patients.
Objective:
To study the ECG features in children with dilated cardiomyopathy (DCM), and related factors for the occurrence of arrhythmia secondary to DCM.
Methods:
Data from 68 children with DCM from January 1998 to March 2011 were studied. The children were classified into three groups: severe arrhythmia (n=42), non-severe arrhythmia (n=20) and non-arrhythmia (n=6). Left ventricular end diastolic diameter (LVED), left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were compared.
Results:
Abnormal ECG results were found in all of the 68 children with DCM. Sinus tachycardia (91%) and ectopic pulsatile (86%) were common. LVED in the severe arrhythmia group (74±6 mm) was greater than that in the non-severe arrhythmia group (65±4 mm; P<0.05) and non-arrhythmia group (61±3 mm; P<0.05). LVED in the non-severe arrhythmia group was also greater than that in the non-arrhythmia group (P<0.05). LVEF and LVFS in the severe arrhythmia group were (30±11)% and (22±4)%, respectively, which were lower than those in the non-severe arrhythmia group[(37±12)% and (28±5)%, respectively]and non-arrhythmia group[(45±9)% and (34±7)%, respectively](P<0.05). There were also significant differences in the LVEF and LVFS between the non-severe arrhythmia and non-arrhythmia groups (P<0.05).
Conclusions:
The common abnormal ECG findings are sinus tachycardia and ectopic pulsatile in children with DCM. Arrhythmia is one of the main clinical manifestations of DCM. The occurrence of arrhythmia is associated with the left ventricular size and heart function.
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