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5-HT(4) receptors, a place in the sun: act two
Joël Bockaert1, Sylvie Claeysen, Valérie Compan
1Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS UMR5203, Montpellier F-34094, France. joel.bockaert@igf.cnrs.fr
Abstract:
5-HT(4) receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT(4) receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several therapeutic 5-HT(4) receptor drugs have been commercialized. Therefore, the hope that 5-HT(4) receptors could also be the target for brain diseases is reasonable. Several major devastating illnesses could benefit from 5-HT(4) receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders.
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