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Monitoring Neutrophil Elastase and Cathepsin G Activity in Human Sputum Samples
Published on: May 21, 2021
In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis
Stephane Desgranges1, Florie Le Prieult, Alan Daly
1Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2, Ireland.
Antimicrobial Agents and Chemotherapy
|February 24, 2011
Abstract:
The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
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