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Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

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Accuracy of apparent diffusion coefficient value measurement on PACS workstation: A comparative analysis.

Reem M El Kady¹, Arabinda Kumar Choudhary, Rafel Tappouni

¹Department of Radiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, PA 17033, USA.

AJR. American Journal of Roentgenology

|February 24, 2011

Summary

Measurements of apparent diffusion coefficient (ADC) in liver lesions using a Picture Archiving and Communication System (PACS) workstation are as accurate as those from a dedicated workstation. This finding supports routine PACS use for improved efficiency and understanding of liver diseases.

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Area of Science:

Radiology
Medical Imaging
Diffusion-Weighted MRI

Background:

Apparent diffusion coefficient (ADC) measurements are crucial for characterizing liver lesions.
Dedicated workstations are currently the standard for ADC measurements.
Evaluating alternative, more accessible platforms is essential for clinical workflow optimization.

Purpose of the Study:

To assess the diagnostic accuracy of ADC measurements performed on a Picture Archiving and Communication System (PACS) workstation.
To compare PACS-based ADC measurements against those obtained from a dedicated postprocessing workstation.

Main Methods:

Retrospective analysis of liver lesions in 79 patients across three MRI platforms.
ADC values were measured using both a dedicated workstation and a PACS system.
Statistical comparison using a two-sample t test to identify significant differences.

Main Results:

No statistically significant difference was found between ADC values measured on the PACS workstation and the dedicated workstation (p=0.268).
The study included 120 liver lesions from 79 patients.
Measured ADC values ranged from 0.4-4.38 × 10(-3) mm(2)/s.

Conclusions:

Routine PACS workstations provide accurate ADC measurements comparable to dedicated systems.
Implementing PACS for ADC measurements can enhance efficiency and potentially improve disease process understanding and clinical management.
This validation supports wider adoption of PACS for quantitative MRI analysis.