Papillary carcinoma of thyroid: classical and variants

Area of Science:

• Oncology
• Pathology
• Endocrinology

Background:

• Papillary carcinoma is the most frequent primary thyroid cancer.
• It presents with a wide range of morphological appearances.
• Understanding these variations is crucial for diagnosis and treatment.

Purpose of the Study:

• To review the clinicopathological features of classical papillary carcinoma.
• To summarize the characteristics of various papillary carcinoma variants.
• To provide a comprehensive overview of thyroid papillary carcinoma morphology.

Main Methods:

• Literature review of clinicopathological features.
• Synthesis of information on classical and variant forms.
• Categorization of morphological subtypes.

Main Results:

• Papillary carcinoma exhibits significant morphological diversity.
• Key variants include follicular, solid, diffuse sclerosing, and tall cell types.
• Other variants discussed cover a spectrum from encapsulated to dedifferentiated forms.

Conclusions:

• Papillary carcinoma encompasses a broad spectrum of histological subtypes.
• Recognition of these variants is essential for accurate pathological diagnosis.
• This review consolidates knowledge on papillary thyroid carcinoma morphology.