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Updated: Jun 4, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Ethical issues in the conduct of clinical trials in obstructive sleep apnea
Devin L Brown1, Craig S Anderson, Ronald D Chervin
1Stroke Program, University of Michigan, Ann Arbor, MI 48109-5855, USA. devinb@umich.edu
Abstract:
Scientifically rigorous clinical trials are needed to test continuous positive airway pressure's (CPAP) effect on important clinical endpoints known to be associated with obstructive sleep apnea, such as myocardial infarction, cardiac arrhythmias, stroke, mortality, seizures, and cognitive function. In this "Special Article," we review the regulatory and ethical issues that surround the design and conduct of CPAP trials, including selection of the appropriate control condition, exclusion criteria, and follow-up duration.
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