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Natural withanolides: an overview.

Li-Xia Chen1, Hao He, Feng Qiu

  • 1Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Road Wenhua, Shenyang, 110016, PR China.

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|February 24, 2011
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Summary
This summary is machine-generated.

Researchers identified 360 new naturally occurring withanolides between 1996 and 2010. This review details their structures, distribution, and diverse biological activities.

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Withanolides are C28 steroids derived from an ergostane skeleton.
  • Key functionalization occurs at carbons 1, 22, and 26, defining the withanolide skeleton.
  • Natural products chemistry focuses on isolating and characterizing compounds from natural sources.

Purpose of the Study:

  • To comprehensively review new naturally occurring withanolides isolated between August 1996 and March 2010.
  • To classify the structures and map the distribution of these newly identified compounds.
  • To discuss the biological and pharmacological activities in relation to their structural features.

Main Methods:

  • Literature review of scientific publications from August 1996 to March 2010.
  • Analysis of structural data for classification and distribution.
  • Correlation of structural features with reported biological activities.

Main Results:

  • Isolation and identification of 360 new naturally occurring withanolides within the specified period.
  • Detailed structural classification and geographical/botanical distribution data presented.
  • Discussion of diverse pharmacological activities, including anti-inflammatory, anti-cancer, and neuroprotective effects.

Conclusions:

  • The period 1996-2010 saw significant expansion in the discovery of novel withanolides.
  • Structural diversity correlates with a broad spectrum of biological activities.
  • Further research into withanolides holds promise for drug discovery.