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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Published on: June 16, 2011

Chikungunya virus isolates with/without A226V mutation show different sensitivity to IFN-a, but similar replication

Licia Bordi1, Silvia Meschi, Marina Selleri

  • 1Laboratory of Virology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.

The New Microbiologica
|February 24, 2011
PubMed

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...