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Streptococcus pyogenes emm types and subtypes of isolates from paediatric asymptomatic carriers and children with

Giovanna Blandino1, Salvatore Puglisi, Annamaria Speciale

  • 1Department of Microbiological and Gynecological Sciences, Section of Microbiology, University of Catania, Catania, Italy. blandino@unict.it

The New Microbiologica
|February 24, 2011
PubMed

Insights

This study identified distinct emm subtypes in Streptococcus pyogenes from carriers and pharyngitis patients. emm subtype 12.0 was more prevalent in carriers, while emm subtype 1.0 was more common in pharyngitis cases.

Area of Science:

  • Microbiology
  • Molecular Epidemiology
  • Public Health

Background:

  • Streptococcus pyogenes causes pharyngitis and other infections.
  • emm subtypes are crucial for understanding S. pyogenes epidemiology.
  • Previous research explored fibronectin-binding genes and antimicrobial susceptibility.

Purpose of the Study:

  • To determine and compare emm subtypes of S. pyogenes from asymptomatic carriers and children with pharyngitis.
  • To investigate potential associations between specific emm subtypes and clinical presentation.

Main Methods:

  • Isolation and identification of Streptococcus pyogenes strains.
  • emm subtype determination using established molecular methods.
  • Analysis of emm subtype distribution in relation to patient group (carrier vs. pharyngitis).

Main Results:

  • Fourteen emm subtypes were detected across all strains.
  • Significant differences in emm subtype prevalence were observed between groups.
  • emm subtype 12.0 was highly prevalent in asymptomatic carriers (50.0%) but rare in pharyngitis cases (3.1%).
  • emm subtype 1.0 was more frequent in pharyngitis cases (28.1%) compared to carriers (0%).

Conclusions:

  • emm subtype profiles differ between asymptomatic Streptococcus pyogenes carriers and children with pharyngitis.
  • Specific emm subtypes may be associated with distinct epidemiological patterns or clinical outcomes.
  • Further research is warranted to elucidate the role of emm subtypes in S. pyogenes pathogenesis and transmission.

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