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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Noninvasive assessment of HIV-related coronary artery disease
Louis H Miller1, John T Coppola
1NYU Langone Medical Center, 530 First Avenue, HCC 14, New York, NY 10016, USA.
Insights
Cardiovascular disease is a major concern for HIV patients on antiretroviral therapy. Noninvasive vascular imaging can help assess and manage this risk, improving patient outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Imaging
Background:
- Highly active antiretroviral therapy (HAART) has reduced HIV mortality but increased cardiovascular disease (CVD) risk.
- CVD in HIV patients stems from traditional risk factors, HIV-specific elements, antiretroviral therapy, inflammation, and viral effects.
- Accurate cardiovascular risk assessment in HIV patients is a clinical challenge.
Purpose of the Study:
- To review noninvasive vascular imaging techniques for cardiovascular risk assessment in HIV patients.
- To aid practitioners in identifying high-risk HIV individuals for targeted therapy.
- To explore how imaging can help reduce cardiac events in this population.
Main Methods:
- Review of current noninvasive vascular imaging modalities.
- Analysis of their utility in assessing cardiovascular risk in HIV-infected individuals.
- Synthesis of evidence to guide clinical practice.
Main Results:
- Noninvasive vascular imaging offers enhanced capabilities for cardiovascular risk stratification in HIV patients.
- These techniques can identify individuals at higher risk, enabling proactive management.
- The review examines specific imaging tests relevant to this population.
Conclusions:
- Noninvasive vascular imaging is crucial for comprehensive cardiovascular risk assessment in HIV patients.
- Utilizing these tools can lead to more effective, targeted interventions.
- Improved risk assessment and management can mitigate cardiac events in the HIV population.
Abstract:
Highly active antiretroviral therapy has led to significant declines in infection-related mortality in HIV-infected patients. Cardiovascular disease has emerged as a leading cause of morbidity and mortality in this population, and is likely related to both an increased prevalence of traditional cardiovascular risk factors and HIV-specific factors associated with antiretroviral therapy, chronic inflammation, and direct viral effects. Accurate clinical assessment of cardiovascular risk in HIV-infected patients is a critical challenge now facing practitioners. Multiple modes of noninvasive vascular imaging are available to enhance the ability to identify patients at high cardiovascular risk, and may ultimately assist in targeting use of intensive medical therapy to reduce cardiac events in this population. This review will examine several of these noninvasive tests and is intended to aid practitioners making cardiovascular risk assessments in HIV patients.
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