Selective oxidation of steroidal allylic alcohols using pyrazole and pyridinium chlorochoromate
E J Parish1, S Chitrakorn, S Lowery
1Department of Chemistry, Auburn University, 36849, Auburn, AL.
Abstract:
ABASTRACT: This paper presents a modified method for the selective oxidation of allylic alchols. Pyrazole, when used with pyridinium chlorochromate, is a mild and useful reagent system for the rapid and selective oxidation of steroidal allylic alcohols to the corresponding α, β-unsaturated ketones. The reaction of each substrate was carried out by adding the oxidant to a dry methylene chloride solution containing pyrazole and an allylic alchol. This report is the first on the use of pyrazole to augment selective oxidation by a chronium (VI) reagent.
More Related Videos
Related Concept Videos
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Radical Anti-Markovnikov Addition to Alkenes: Overview
Oxidation of Alcohols
The process of oxidation in a chemical reaction is observed in any of the three forms:
Radical Oxidation of Allylic and Benzylic Alcohols
Acid Halides to Esters: Alcoholysis
Oxidative Cleavage of Alkenes: Ozonolysis
Ozone is a symmetrical bent molecule stabilized by a resonance structure.


