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Related Experiment Video

Updated: Jun 4, 2026

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

Decrease in serum FGF23 levels after intravenous infusion of pamidronate in patients with osteogenesis imperfecta.

Taichi Kitaoka¹, Noriyuki Namba, Kohji Miura

¹Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Journal of Bone and Mineral Metabolism

|February 24, 2011

Summary

Pamidronate infusion rapidly decreases fibroblast growth factor 23 (FGF23) levels in osteogenesis imperfecta patients. This FGF23 reduction appears independent of phosphate changes, suggesting bone resorption inhibition or direct pamidronate effects regulate FGF23 secretion.

Related Experiment Videos

Last Updated: Jun 4, 2026

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

Area of Science:

Endocrinology
Bone Metabolism
Mineral Homeostasis

Background:

Fibroblast growth factor 23 (FGF23) is crucial for phosphate (P) balance.
Mechanisms regulating FGF23 secretion require further elucidation.

Purpose of the Study:

To investigate the impact of pamidronate administration on serum FGF23 levels.

Main Methods:

Thirteen osteogenesis imperfecta patients received two cycles of 3-day pamidronate infusions.
Serum levels of FGF23, P, calcium, iPTH, 1,25(OH)(2)D, NTx, BAP, and TmP/GFR were measured pre- and post-infusion.

Main Results:

FGF23 levels significantly decreased following pamidronate infusion, preceding a drop in P levels.
FGF23 reduction was consistent across both cycles and independent of P level changes.
A correlation between NTx suppression and FGF23 decrease suggests osteoclast inhibition's role.
Pamidronate dose correlated with FGF23 reduction, indicating potential direct effects on FGF23 production by osteocytes/osteoblasts.

Conclusions:

Pamidronate infusion rapidly lowers serum FGF23 levels in patients with osteogenesis imperfecta.
The observed FGF23 suppression may result from inhibited bone resorption and/or direct actions of pamidronate on bone cells.