Related Experiment Video
Updated: Jun 4, 2026
Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
Published on: June 13, 2017
Treatment success for age-related vocal fold atrophy
Jackie Gartner-Schmidt1, Clark Rosen
1University of Pittsburgh Voice Center, University of Pittsburgh Medical Center, Department of Otolaryngology, Pittsburgh, Pennsylvania, USA. jgs@pitt.edu
Objectives/Hypothesis:
To characterize perceived voice handicap of patients diagnosed with vocal fold atrophy and review treatment success.
Study Design:
Retrospective study.
Methods:
Two hundred seventy-five patients diagnosed with vocal fold atrophy (January 2007-January 2009) were reviewed from a preexisting clinical database. Outcome measures included pre/post-treatment Voice Handicap Index-10 and data from a voice therapy discharge survey.
Results:
Five groups emerged from the data set. Group A: patients who had no follow-up (69%). After removing group A from the data set, the following groups emerged: group B: patients who had no treatment but some follow-up (31%); group C: patients who had voice therapy only (44%); group D: patients who had surgery only (15%); and group E: patients who had voice therapy first and subsequent surgery (9%). The perceived voice handicap severity was worse for groups C and D compared to groups A, B, and E. Treatment success outcomes showed that groups C (36%), D (56%), and E (17%) only improved marginally. However, 81% of patients diagnosed with atrophy believed that voice therapy helped them but only by 48%.
Conclusions:
Treatment success for age-related vocal fold atrophy is poor to moderately poor for this cohort of patients.
Related Concept Videos
01:21Larynx
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
01:29Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
01:20Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
01:23Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
01:30Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques