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PseudoBartter syndrome in eating disorders
Amit Bahia1, Margherita Mascolo, Jennifer L Gaudiani
1Department of Medicine, Denver Health, The ACUTE Center for Eating Disorders, Denver, Colorado 80204, USA. amit.bahia@dhha.org
The International Journal of Eating Disorders
|February 24, 2011
Summary
PseudoBartter's syndrome, characterized by metabolic abnormalities, is linked to purging behaviors in eating disorders. This self-perpetuating cycle can cause dehydration, chloride depletion, and edema.
Area of Science:
- Nephrology
- Endocrinology
- Psychiatry
Background:
- PseudoBartter's syndrome presents as a complex metabolic derangement.
- It is frequently observed in patients with eating disorders, particularly those engaging in purging behaviors.
Observation:
- Two cases are presented with distinct histories and presentations.
- Both cases share the underlying pathophysiology leading to PseudoBartter's syndrome.
Findings:
- Purging behaviors induce dehydration and chloride depletion.
- This leads to metabolic abnormalities mimicking inherited renal tubular transport disorders.
- Eating disorder patients develop a propensity for significant edema formation.
Implications:
- PseudoBartter's syndrome manifestations are more common than previously recognized.
- Understanding the self-perpetuating pathophysiology is crucial for diagnosis.
- The tendency for edema formation must be considered in clinical management.
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