Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa
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Updated: Jun 4, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
Vikas Duvvuri1, Taya Cromley, Megan Klabunde
1Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA.
Objective:
No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison.
Method:
This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy.
Results:
Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months.
Discussion:
This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa.
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