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Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Peripheral DNA damage in active pulmonary tuberculosis.

Sahbettin Selek1, Mehmet Aslan, Mehmet Horoz

  • 1Department of Biochemistry, School of Medicine, Harran University, Sanliurfa, Turkey.

Environmental Toxicology
|February 24, 2011
PubMed
Summary

Pulmonary tuberculosis patients exhibit elevated DNA damage and oxidative stress. This increased DNA damage, linked to oxidative stress, may contribute to the complications associated with tuberculosis.

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Area of Science:

  • Biochemistry
  • Genetics
  • Pulmonology

Background:

  • Oxidative stress is documented in pulmonary tuberculosis.
  • Peripheral DNA damage in these patients remains understudied.

Purpose of the Study:

  • To investigate DNA damage and oxidative status in pulmonary tuberculosis patients.
  • To explore the relationship between DNA damage and oxidative stress markers.

Main Methods:

  • Comet assay for DNA damage assessment.
  • Measurement of total oxidant status, total antioxidant status, and oxidative stress index.
  • Comparison between 27 pulmonary tuberculosis patients and 26 controls.

Main Results:

  • Pulmonary tuberculosis patients showed significantly higher DNA damage, total oxidant status, and oxidative stress index compared to controls.
  • Total antioxidant status was significantly lower in patients.
  • DNA damage correlated positively with total oxidant status and oxidative stress index, and negatively with total antioxidant status.

Conclusions:

  • Pulmonary tuberculosis is associated with increased oxidative stress and peripheral DNA damage.
  • Oxidative stress-induced DNA damage may play a role in the pathogenesis of tuberculosis-associated disorders.