Voltammetric quantification of tamoxifen

Area of Science:

• Electrochemistry
• Analytical Chemistry
• Pharmaceutical Analysis

Background:

• Tamoxifen is a widely used medication, necessitating reliable analytical methods for quality control.
• Electrochemical techniques offer sensitive and efficient approaches for drug analysis.

Purpose of the Study:

• To develop and validate a novel electrochemical method for tamoxifen determination.
• To investigate the electrochemical oxidation mechanism of tamoxifen.
• To assess the method's applicability in pharmaceutical formulations.

Main Methods:

• Cyclic voltammetry (CV)
• Differential pulse voltammetry (DPV)
• Square-wave voltammetry (SWV)
• Gold electrode as working electrode
• Investigation of parameters like pH, concentration, scan rate, solvent, and surfactants.

Main Results:

• Tamoxifen undergoes a single two-electron, irreversible, diffusion-controlled oxidation.
• Linear calibration plots were achieved within specific concentration ranges in KCl and Britton Robinson buffers.
• The method demonstrated high accuracy with mean percentage recoveries of 99.98% for tablet formulations.

Conclusions:

• The developed electrochemical method is sensitive, accurate, and reliable for tamoxifen quantification.
• This technique is suitable for the routine determination of tamoxifen in various drug products.
• The study provides a valuable analytical tool for pharmaceutical quality assurance.