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A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
Published on: May 31, 2016
Two cases of unexpected long-term improvement of Parkinson's disease after subthalamic nucleus deep brain stimulation
S H Wong1, P R Eldridge, A Duffy
1Departments of Neurology, The Walton Centre, Liverpool, UK. suiwong@doctors.org.uk
British Journal of Neurosurgery
|February 25, 2011
Abstract:
Two patients with Parkinson's disease (PD) treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS) for 3-4 years are reported, who demonstrated a persistent improvement following removal of STN-DBS for late infection. Possible hypotheses are discussed--whether a microlesioning effect or a disease-modifying effect of STN-DBS, though neither adequately explain this phenomenon.

