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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Genomic DNA in Prokaryotes

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...

Complementary DNA

Complementary DNA

Complementary DNA

Complementary DNA

Genomic DNA in Eukaryotes

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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Company profile: Complete Genomics Inc.

Clifford Reid¹

¹Complete Genomics Inc., 2071 Stierlin Court, Mountain View, CA 94043, USA. creid@completegenomics.com

Future Oncology (London, England)

|February 25, 2011

Summary

This summary is machine-generated.

Complete Genomics Inc. offers a specialized service for complete human genome sequencing. Their platform provides high-quality, cost-effective DNA sequencing and analysis for biological discovery.

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Area of Science:

Genomics
Life Sciences
Biotechnology

Background:

The field of genomics is rapidly advancing, with a growing demand for high-quality human genome sequencing.
Existing sequencing platforms often aim for broad applicability, potentially compromising efficiency for specific applications.
Complete Genomics Inc. has adopted a focused strategy to address the need for comprehensive human genome analysis.

Purpose of the Study:

To introduce Complete Genomics Inc.'s specialized approach to complete human genome sequencing.
To highlight the capabilities of the Complete Genomics Analysis Platform (CGA™ Platform).
To present a turnkey service for outsourcing human genome sequencing and data analysis.

Main Methods:

Development of the Complete Genomics Analysis Platform (CGA™ Platform), integrating biochemistry, instrumentation, and software.
Focus on a single application: complete human genome sequencing.
Establishment of a dedicated genome sequencing center for outsourced services.

Main Results:

The CGA™ Platform enables human genome sequencing at high quality, low cost, and large scale.
Complete Genomics provides a comprehensive service from DNA sample submission to research-ready data.
The service includes library preparation, DNA sequencing, assembly, and variant analysis.

Conclusions:

Complete Genomics Inc. offers a specialized and efficient solution for complete human genome sequencing.
The company's focused approach and integrated platform deliver high-quality, cost-effective genomic data.
Outsourcing human genome sequencing to Complete Genomics facilitates biological discovery for researchers.