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Updated: Jun 4, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Allopurinol hypersensitivity syndrome with acute generalized exanthematous pustulosis manifestations
Wan Lin Teo1, Shiu Ming Pang, Hong Yi Koh
1Singapore General Hospital, Dermatology Unit, Singapore. wanlinteo@gmail.com
Abstract:
Allopurinol hypersensitivity syndrome(AHS) is a severe form of cutaneous adverse reaction that is associated with significant morbidity and mortality. We report a case of AHS with the cutaneous manifestation of acute generalised exanthematous pustulosis(AGEP). A 47 year old gentleman, with no previous skin disease, presented with a generalized mildly pruritic erythematous rash on the trunk and all 4 limbs, with patches of superficial non-follicular pustules. Our patient fulfilled both criteria for AGEP and AHS.
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