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Does occupational exposure to low-dose ionizing radiation affect bone marrow thrombopoiesis?
Douaa Sayed1, Mostafa E Abd Elwanis, Saly Y Abd Elhameed
1Flow Cytometry Lab,, Department of Clinical pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt. douaa_sayed@hotmail.com.
International Archives of Medicine
|February 25, 2011
Summary
Low-level radiation exposure can affect platelet production. Measuring reticulated platelets (RP) using flow cytometry offers a quick, non-invasive method to detect early bone marrow (BM) changes in radiation workers.
Area of Science:
- Hematology
- Radiation Oncology
- Occupational Health
Background:
- Biological effects of high-dose radiation are known, but low-dose effects are less understood.
- Deterministic effects are absent at low radiation levels, complicating risk assessment.
- Assessing low-level radiation impact on bone marrow (BM) thrombopoiesis requires sensitive indicators.
Purpose of the Study:
- To evaluate the risk of low-level ionizing radiation exposure on bone marrow (BM) thrombopoiesis.
- To assess the utility of reticulated platelets (RP) as an early indicator of radiation-induced thrombopoietic changes.
- To investigate occupational health risks for hospital workers in a radiotherapy department.
Main Methods:
- Measured reticulated platelets (RP) via flow cytometry.
- Studied 14 hospital workers (12 technicians, 2 nurses) in a radiotherapy department.
- Assessed exposure to low-level ionizing radiation.
Main Results:
- A significant difference was observed in the percentage of RP in peripheral circulation (p = .008).
- No significant changes were found in other blood elements.
- Reticulated platelet levels indicate a measurable effect on thrombopoiesis.
Conclusions:
- Measuring RP via flow cytometry is a rapid, non-invasive method to assess early thrombopoiesis affection.
- RP monitoring can serve as an indicator for early BM affection detection.
- This method can inform enhanced radiation protection measures for exposed workers.
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