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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research
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Published on: June 10, 2016

Engineering a stem cell house into a home.

Penny M Gilbert1, Helen M Blau

  • 1Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. penney.gilbert@gmail.com

Stem Cell Research & Therapy
|February 25, 2011
PubMed
Summary
This summary is machine-generated.

Resident tissue-specific adult stem cells (aSCs) maintain tissue homeostasis by integrating niche cues. Understanding niche regulation is key to guiding aSC behavior for regenerative medicine applications.

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Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Biomaterials science

Background:

  • Adult stem cells (aSCs) are crucial for tissue homeostasis and regeneration.
  • The stem cell niche microenvironment regulates aSC behavior and fate.
  • Current understanding of niche composition and regulatory mechanisms is limited.

Purpose of the Study:

  • To explore the role of the stem cell niche in regulating adult stem cell (aSC) behavior.
  • To identify novel regulatory mechanisms governing stem cell fate.
  • To advance regenerative medicine applications through improved understanding of stem cell niches.

Main Methods:

  • Utilizing two- and three-dimensional biomaterial platforms.
  • Systematic analysis of putative niche elements.
  • Screening approaches to identify regulatory mechanisms.

Main Results:

  • Biomaterial approaches enable systematic analysis of niche components.
  • Novel regulatory mechanisms governing stem cell fate can be identified.
  • The study highlights the potential of bioengineering to elucidate stem cell-niche interactions.

Conclusions:

  • A deeper comprehension of niche composition and regulation is essential for guiding adult stem cell (aSC) behavior.
  • Bioengineering approaches combined with stem cell biology can significantly advance our understanding of stem cell regulation.
  • This research paves the way for novel regenerative medicine strategies by addressing stem cell niche interactions.