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Updated: Jun 4, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
BiC: a web server for calculating bimodality of coexpression between gene and protein networks
George C Linderman1, Vishal N Patel, Mark R Chance
1Department of Biomedical Engineering, Case Center for Proteomics and Bioinformatics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Unlabelled:
Bimodal patterns of expression have recently been shown to be useful not only in prioritizing genes that distinguish phenotypes, but also in prioritizing network models that correlate with proteomic evidence. In particular, subgroups of strongly coexpressed gene pairs result in an increased variance of the correlation distribution. This variance, a measure of association between sets of genes (or proteins), can be summarized as the bimodality of coexpression (BiC). We developed an online tool to calculate the BiC for user-defined gene lists and associated mRNA expression data. BiC is a comprehensive application that provides researchers with the ability to analyze both publicly available and user-collected array data.
Availability:
The freely available web service and the documentation can be accessed at http://gurkan.case.edu/software.
Contact:
gurkan@case.edu.
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