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Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype

Dal Young Kim1, Svetlana Atasheva, Niall J Foy

  • 1Department of Microbiology, BBRB 373/Box 3, University of Alabama, 1530 Third Avenue South, Birmingham, AL 35294-2170, USA.

Journal of Virology
|February 25, 2011
PubMed
Summary

Researchers developed novel attenuated alphaviruses for potential vaccines. These engineered viruses, derived from diverse strains, lack key pathogenic factors and are incapable of mosquito transmission, offering a new strategy for alphavirus control.

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