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Updated: Jun 4, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
Published on: March 1, 2022
Carbohydrate metabolism and the skeleton: picking a bone with the beta-cell
1Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. rkumar@mayo.edu
Abstract:
Novel data show that the bone protein, undercarboxylated osteocalcin, increases islet cell growth and insulin and adiponectin synthesis and enhances glucose metabolism in mice. Human studies, in which undercarboxylated osteocalcin concentrations have been perturbed, show no effect (or a very minor effect) on fasting glucose or insulin concentrations. More extensive and detailed experiments in humans are needed to definitively establish the role of undercarboxylated osteocalcin in human carbohydrate metabolism.
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