Related Experiment Video

Updated: Jun 4, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Ischemic stroke outcome and early infection: its deleterious effect seems to operate also among tissue plasminogen

David Salat1, Pilar Delgado, Sara Alonso

  • 1Neurovascular Research Laboratory and Neurovascular Unit, Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain.

European Neurology
|February 25, 2011
PubMed
Abstract

Insights

Infections are linked to poorer outcomes in ischemic stroke patients receiving tissue plasminogen activator treatment. This study highlights infection as a key factor influencing neurological improvement and survival post-stroke.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Infection is a known predictor of outcomes in ischemic stroke patients.
  • Mechanisms linking infection and stroke outcomes require further elucidation.
  • The role of infection in stroke units with reperfusion therapies is understudied.

Purpose of the Study:

  • To evaluate predictors of neurological outcome in ischemic stroke patients.
  • To assess the association between infection and outcomes in stroke patients receiving thrombolysis.
  • To investigate the impact of infections on neurological improvement and mortality.

Main Methods:

  • Retrospective review of medical records.
  • Study population: 139 consecutive tissue plasminogen activator-treated ischemic stroke patients.
  • Analysis of neurological outcome, infections, and hemorrhagic transformation.

Main Results:

  • 41% of patients showed no neurological improvement by discharge; 11.5% died.
  • Infections were significantly associated with lack of neurological improvement (29.8% vs. 14.6%, p=0.03).
  • Infections correlated with PH-type hemorrhagic transformation (42.1% vs. 17.5%, p=0.014), which increased mortality (26.3% vs. 9.2%, p=0.03).

Conclusions:

  • Infection may be associated with poor functional outcomes in ischemic stroke patients.
  • Infection is a significant factor influencing neurological recovery after stroke.
  • Preventing and managing infections is crucial for improving outcomes in stroke care.

More Related Videos

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...