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Related Experiment Videos

Structure-function aspects of the glucocorticoid receptor.

J A Gustafsson1, K Dahlman-Wright, P E Strömstedt

  • 1Department of Medical Nutrition, Karolinska Institute, Novum, Huddinge University Hospital, Sweden.

Princess Takamatsu Symposia
|January 1, 1990
PubMed
Summary
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The glucocorticoid receptor, a key nuclear receptor, is crucial for understanding P-450 regulation. Its structural aspects, especially the DNA-binding domain, are being investigated using gene technology and NMR.

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Biochemistry

Background:

  • The glucocorticoid receptor is a ligand-activated nuclear receptor.
  • This family includes receptors for steroid hormones, thyroid hormone, retinoic acid, and vitamin D.
  • Other potential members include orphan receptors and possibly the dioxin receptor.

Purpose of the Study:

  • To investigate the structural aspects of the glucocorticoid receptor.
  • To understand principles of P-450 regulation by studying glucocorticoid action.
  • To explore the role of the steroid receptor supergene family in P-450 induction.

Main Methods:

  • Gene technology for receptor domain overexpression.
  • Nuclear Magnetic Resonance (NMR) for structural resolution.

Related Experiment Videos

  • Analysis of P-450 regulation mechanisms.

    • Main Results:

    • The DNA-binding domain of the glucocorticoid receptor has been structurally resolved using NMR.
    • The clofibrate receptor is part of the steroid receptor supergene family.
    • Glucocorticoid receptor is a well-studied model for nuclear receptor family.

    Conclusions:

    • Understanding glucocorticoid receptor mechanisms is vital for P-450 regulation.
    • Further research may identify novel P-450 inducers acting via related receptors.
    • Structural studies of the glucocorticoid receptor provide fundamental insights.