BioEMR: an integrative framework for cancer research with multiple genomic technologies

Yu Rang Park1, Yun Jung Bae, Ju Han Kim

  • 1Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine;

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...