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Updated: Jun 4, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
The role of autophagy in genetic pathways influencing ageing
Maria Markaki1, Nektarios Tavernarakis
1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, N. Plastira 100, Vassilika Vouton, P.O. Box 1385, 70013, Heraklion, Crete, Greece.
Abstract:
Autophagy is a conserved cellular degradation pathway for the breakdown of cytosolic macromolecules and organelles. Constitutive autophagy has a housekeeping role and is essential for survival, development and metabolic regulation. Autophagy is also responsive to stress and can degrade damaged proteins and organelles, oxidized lipids and intracellular pathogens. Defects in the autophagic degradation system are linked to disease pathogenesis and ageing. Different signalling pathways converge on autophagy to regulate lifespan in diverse organisms. We discuss recent findings that provide insight into the cross-talk between this critical regulator of metabolic homeostasis and molecular mechanisms that promote longevity.
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