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Related Concept Videos

Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

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Related Experiment Video

Updated: Jun 4, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

[Vitamin D deficiency, left ventricular dysfunction and heart failure].

Giovanni Cioffi1, Davide Gatti, Silvano Adami

  • 1Divisione di Cardiologia, Casa di Cura Villa Bianca, Trento. gcioffi@villabiancatrento.it

Giornale Italiano Di Cardiologia (2006)
|February 26, 2011
PubMed
Summary

Vitamin D deficiency affects millions globally, impacting bone health, immunity, and potentially causing heart failure. Addressing this deficiency is crucial for overall health and quality of life.

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

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Last Updated: Jun 4, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
08:17

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

Published on: February 20, 2017

Area of Science:

  • Endocrinology and Metabolism
  • Cardiology
  • Public Health

Context:

  • Vitamin D deficiency is a widespread, underdiagnosed condition affecting approximately one million people worldwide.
  • Low vitamin D status is linked to numerous health issues, including osteoporosis, cancer, diabetes, and vascular inflammation.
  • Cardiovascular diseases like hypertension and heart failure may stem from insufficient vitamin D levels, yet it's not routinely screened.

Purpose:

  • To review the relationship between vitamin D deficiency and asymptomatic changes in left ventricular geometry and function.
  • To explore the role of vitamin D in myocardial metabolic processes.
  • To highlight the potential link between vitamin D deficiency and heart failure syndrome.

Summary:

  • Vitamin D deficiency is prevalent and linked to serious health consequences, including cardiovascular issues.
  • Vitamin D plays a vital role in cardiac function by regulating calcium metabolism and contractile protein synthesis.
  • This review examines how vitamin D deficiency may lead to subclinical cardiac changes and contribute to heart failure.

Impact:

  • Highlights the underdiagnosis of vitamin D deficiency and its significant clinical impact, particularly on cardiovascular health.
  • Underscores the importance of considering vitamin D status in patients with or at risk for heart failure.
  • Calls for future research to investigate the therapeutic effects of vitamin D repletion on cardiac function.