Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vitamin B6 deficiency as a cause of erythropoietin-stimulating agent-resistant anemia in hemodialysis patients: A report of two cases.

Internal medicine (Tokyo, Japan)·2026

Same author

An Exploratory Study of the Effects of a High School-University Collaborative Program on Learning Motivation and Professional Understanding among Students Aspiring to Enter Medical School.

Juntendo medical journal·2026

Same author

Azathioprine withdrawal leading to spontaneous remission of Iatrogenic Epstein-Barr virus-negative diffuse large B-cell lymphoma: A case report and literature review.

Internal medicine (Tokyo, Japan)·2026

Same author

Mesenteric AL Amyloidosis with Diffuse Calcifications: A Case Report and Review of the Literature.

Internal medicine (Tokyo, Japan)·2026

Same author

Dual-antigen recognition iPSC-derived CAR-T cells for B-cell malignancies: establishment of a COVID-19 vaccine synergy strategy.

Frontiers in cell and developmental biology·2026

Same author

Radiation-Induced Angiosarcoma Following Breast Surgery: A Case Report.

Surgical case reports·2026

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

[Diffuse large B-cell lymphoma initially manifesting in bone marrow. A case report].

Kanako Ogura¹, Noriko Miyake, Hajime Yasuda

¹Department of Laboratory Medicine, Juntendo University Nerima Hospital, Nerima-ku, Tokyo 177-8521, Japan. kanakogu@juntendo-nerima.jp

Rinsho Byori. the Japanese Journal of Clinical Pathology

|February 26, 2011

Summary

This case highlights diffuse large B-cell lymphoma (DLBCL) presenting solely in the bone marrow. Simultaneous bone marrow biopsy and myelogram with immunohistochemistry aided accurate diagnosis.

Related Experiment Videos

Last Updated: Jun 4, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

Hematology
Oncology
Pathology

Background:

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
DLBCL typically presents with lymphadenopathy or extranodal involvement.
Bone marrow involvement can occur but is often accompanied by other signs of disease.

Observation:

A 68-year-old woman presented with fatigue and fever, with atypical cells in peripheral blood.
Bone marrow examination revealed diffuse infiltration by atypical cells, initially mimicking myelodysplastic disease.
Skin biopsy was negative for atypical cells, indicating no cutaneous involvement.

Findings:

Immunohistochemical analysis of bone marrow biopsy confirmed atypical cells were CD20-positive B-cells.
The diagnosis was established as DLBCL primarily manifesting in the bone marrow.
Simultaneous evaluation of bone marrow biopsy and myelogram was crucial for diagnosis.

Implications:

This case underscores the importance of considering DLBCL in the bone marrow, even without typical signs.
Combined diagnostic approaches, including immunohistochemistry, are vital for accurate and timely DLBCL diagnosis.
Early detection of bone marrow-centric DLBCL can potentially influence treatment strategies and patient outcomes.